> For clean Markdown of any page, append .md to the page URL.
> For a complete documentation index, see https://docs.nvidia.com/clara/parabricks/llms.txt.
> For AI client integration (Claude Code, Cursor, etc.), connect to the MCP server at https://docs.nvidia.com/clara/parabricks/_mcp/server.

# 4.1.0-1 Release Notes

Clara Parabricks 4.1.0-1 now supports GPUs with Ada Lovelace and Hopper architecture.
The DeepVariant tool no longer needs different models for different GPUs.
Visit the updated Installation Requirements section for exact requirements.

We've also sped up several tools and are now using the GPU to sort and write BAM
files in [fq2bam](/tool-reference/tools/fq-2-bam-bwa-mem-gatk), [somatic](/tool-reference/tools/somatic-somatic-variant-caller), [germline](/tool-reference/tools/germline-gatk-germline-pipeline)
and [deepvariant\_germline](/tool-reference/tools/deepvariant-germline).

## Improvements

* Ada Lovelace and Hopper architecture GPUs are supported for all tools.

* fq2bam has been accelerated over the previous version by a significant factor.

* deepvariant has been upgraded to 1.5 and supports new PacBio options.

* deepvariant has been accelerated by a significant factor.

* Added cloud usage guides for:

  * [AWS](/Tutorials/CloudGuides/AWS)
  * [DNANexus](/Tutorials/CloudGuides/DNANexus)
  * [GCP](/Tutorials/CloudGuides/GCP)
  * [Terra Bio](/Tutorials/CloudGuides/Terra)

* Added information on how to get the [best performance](/Best_Performance) out of your Clara Parabricks software

## Bug Fixes

* Fixed potential resource leaks in a few tools.

For further information refer to the [Parabricks datasheet](https://resources.nvidia.com/en-us-hc-genomics/healthcare-genomics#page=1).