# BioNeMo NIM Overview

NVIDIA BioNeMo NIMs are a collection of GPU-accelerated inference microservices that bring state-of-the-art AI models for biology and drug discovery behind simple, consistent APIs. Each NIM packages a leading model as a self-hosted, easily deployable container, and because they share a common interface, they can be chained together to build complete *in silico* drug discovery pipelines spanning structure prediction, molecular generation, protein design, genomic analysis, and molecular docking.

## Use Cases

BioNeMo NIMs span structure prediction, molecular generation and design, genomics, and docking.

### Structure Prediction

Use these NIMs when you need 3D structures or alignments from sequence:

<CardGroup cols={3}>
  <Card title="AlphaFold2" href="/alphafold2">
    Predict protein structures from amino acid sequences.
  </Card>
  <Card title="AlphaFold2-Multimer" href="/alphafold2-multimer">
    Predict protein-complex structures from amino acid sequences.
  </Card>
  <Card title="OpenFold2" href="/openfold2">
    An open, PyTorch reimplementation of AlphaFold2 at parity accuracy with improved speed.
  </Card>
  <Card title="OpenFold3" href="/openfold3">
    Predicts complete biomolecular complexes of proteins, DNA, RNA, and small-molecule ligands.
  </Card>
  <Card title="Boltz-2" href="/boltz2">
    Predicts biomolecular complexes and their binding affinity.
  </Card>
  <Card title="MSA Search" href="/msa-search">
    Fast, GPU-accelerated multiple sequence alignment that the folding models rely on to improve accuracy.
  </Card>
</CardGroup>

**Benefits**: Shared HTTP APIs, GPU-accelerated inference, pipeline-ready MSA and folding outputs

### Molecular Generation and Design

Use these NIMs when you need novel small molecules or protein backbones and sequences:

<CardGroup cols={2}>
  <Card title="MolMIM" href="/molmim">
    Generates novel small molecules through a clustered latent space for controlled, property-guided generation.
  </Card>
  <Card title="GenMol" href="/genmol">
    Generates small molecules through fragment-based (SAFE) masked-diffusion generation.
  </Card>
  <Card title="RFdiffusion" href="/rfdiffusion">
    Generates novel protein backbones.
  </Card>
  <Card title="RFD4-Proteina" href="/rfd4-proteina">
    Generates novel protein backbones and sequences for tasks such as motif scaffolding, binder design and antibody CDR design.
  </Card>
  <Card title="ProteinMPNN" href="/proteinmpnn">
    Predicts amino acid sequences that fold into a given protein structure.
  </Card>
</CardGroup>

**Benefits**: Controlled generation, fragment and property constraints, protein design chaining

### Genomics and Docking

Use these NIMs when you need genomic interpretation or protein–ligand poses:

<CardGroup cols={2}>
  <Card title="Evo 2" href="/evo2">
    A genomic foundation model that interprets and generates DNA across scales, from individual molecules to entire genomes.
  </Card>
  <Card title="DiffDock" href="/diffdock">
    Predicts protein-ligand binding poses for molecular docking.
  </Card>
</CardGroup>

**Benefits**: Sequence-to-function exploration and docking poses with confidence estimates

## Instructions for AI Agents

- For clean Markdown of any page, append `.md` to the page URL
- For section-specific indexes, append `/llms.txt` to any section URL
- For AI client integration (Claude Code, Cursor, etc.), connect to the MCP server at https://docs.nvidia.com/nim/bionemo/_mcp/server

## Products

- [AlphaFold2](https://docs.nvidia.com/nim/bionemo/alphafold2/llms.txt)
  - [Overview](https://docs.nvidia.com/nim/bionemo/alphafold2/2.1.0/overview.md)
  - [Prerequisites](https://docs.nvidia.com/nim/bionemo/alphafold2/2.1.0/prerequisites.md)
  - [Quickstart Guide](https://docs.nvidia.com/nim/bionemo/alphafold2/2.1.0/quickstart-guide.md)
  - [Deployment Guide](https://docs.nvidia.com/nim/bionemo/alphafold2/2.1.0/deployment-guide.md)
  - [Endpoints](https://docs.nvidia.com/nim/bionemo/alphafold2/2.1.0/endpoints.md)
- [AlphaFold2-Multimer](https://docs.nvidia.com/nim/bionemo/alphafold2-multimer/llms.txt)
  - [Overview](https://docs.nvidia.com/nim/bionemo/alphafold2-multimer/1.0.0/overview.md)
  - [Prerequisites](https://docs.nvidia.com/nim/bionemo/alphafold2-multimer/1.0.0/prerequisites.md)
  - [Quickstart Guide](https://docs.nvidia.com/nim/bionemo/alphafold2-multimer/1.0.0/quickstart-guide.md)
  - [Deployment Guide](https://docs.nvidia.com/nim/bionemo/alphafold2-multimer/1.0.0/deployment-guide.md)
  - [Inference Endpoints](https://docs.nvidia.com/nim/bionemo/alphafold2-multimer/1.0.0/inference-endpoints.md)
- [Boltz-2](https://docs.nvidia.com/nim/bionemo/boltz2/llms.txt)
  - [Overview](https://docs.nvidia.com/nim/bionemo/boltz2/1.10.0/overview.md)
  - [Support Matrix](https://docs.nvidia.com/nim/bionemo/boltz2/1.10.0/support-matrix.md)
  - [Getting Started](https://docs.nvidia.com/nim/bionemo/boltz2/1.10.0/getting-started.md)
  - [Inference](https://docs.nvidia.com/nim/bionemo/boltz2/1.10.0/inference.md)
  - [Configure](https://docs.nvidia.com/nim/bionemo/boltz2/1.10.0/configure.md)
- [DiffDock](https://docs.nvidia.com/nim/bionemo/diffdock/llms.txt)
  - [Overview](https://docs.nvidia.com/nim/bionemo/diffdock/2.3.0/overview.md)
  - [Support Matrix](https://docs.nvidia.com/nim/bionemo/diffdock/2.3.0/support-matrix.md)
  - [Getting Started](https://docs.nvidia.com/nim/bionemo/diffdock/2.3.0/getting-started.md)
  - [Configure NIM](https://docs.nvidia.com/nim/bionemo/diffdock/2.3.0/configure-nim.md)
  - [API Reference](https://docs.nvidia.com/nim/bionemo/diffdock/2.3.0/api-reference.md)
- [Evo 2](https://docs.nvidia.com/nim/bionemo/evo2/llms.txt)
  - [Overview](https://docs.nvidia.com/nim/bionemo/evo2/2.2.0/overview.md)
  - [Prerequisites](https://docs.nvidia.com/nim/bionemo/evo2/2.2.0/prerequisites.md)
  - [Quickstart Guide](https://docs.nvidia.com/nim/bionemo/evo2/2.2.0/quickstart-guide.md)
  - [Endpoints](https://docs.nvidia.com/nim/bionemo/evo2/2.2.0/endpoints.md)
  - [Benchmarking](https://docs.nvidia.com/nim/bionemo/evo2/2.2.0/benchmarking.md)
- [GenMol](https://docs.nvidia.com/nim/bionemo/genmol/llms.txt)
  - [Overview](https://docs.nvidia.com/nim/bionemo/genmol/2.0.0/overview.md)
  - [Prerequisites](https://docs.nvidia.com/nim/bionemo/genmol/2.0.0/prerequisites.md)
  - [Support Matrix](https://docs.nvidia.com/nim/bionemo/genmol/2.0.0/support-matrix.md)
  - [Getting Started](https://docs.nvidia.com/nim/bionemo/genmol/2.0.0/getting-started.md)
  - [Configure NIM](https://docs.nvidia.com/nim/bionemo/genmol/2.0.0/configure-nim.md)
- [MolMIM](https://docs.nvidia.com/nim/bionemo/molmim/llms.txt)
  - [Overview](https://docs.nvidia.com/nim/bionemo/molmim/1.0.0/overview.md)
  - [Prerequisites](https://docs.nvidia.com/nim/bionemo/molmim/1.0.0/prerequisites.md)
  - [Support Matrix](https://docs.nvidia.com/nim/bionemo/molmim/1.0.0/support-matrix.md)
  - [Quickstart Guide](https://docs.nvidia.com/nim/bionemo/molmim/1.0.0/quickstart-guide.md)
  - [Deployment Guide](https://docs.nvidia.com/nim/bionemo/molmim/1.0.0/deployment-guide.md)
- [MSA Search](https://docs.nvidia.com/nim/bionemo/msa-search/llms.txt)
  - [Overview](https://docs.nvidia.com/nim/bionemo/msa-search/2.6.0/overview.md)
  - [Prerequisites and Support Matrix](https://docs.nvidia.com/nim/bionemo/msa-search/2.6.0/prerequisites-and-support-matrix.md)
  - [Getting Started](https://docs.nvidia.com/nim/bionemo/msa-search/2.6.0/getting-started.md)
  - [Configuration](https://docs.nvidia.com/nim/bionemo/msa-search/2.6.0/configuration.md)
  - [Task-Specific Profiles and Custom Databases](https://docs.nvidia.com/nim/bionemo/msa-search/2.6.0/task-specific-profiles-and-custom-databases.md)
- [OpenFold2](https://docs.nvidia.com/nim/bionemo/openfold2/llms.txt)
  - [Overview](https://docs.nvidia.com/nim/bionemo/openfold2/2.6.0/overview.md)
  - [Prerequisites](https://docs.nvidia.com/nim/bionemo/openfold2/2.6.0/prerequisites.md)
  - [Support Matrix](https://docs.nvidia.com/nim/bionemo/openfold2/2.6.0/support-matrix.md)
  - [Getting Started](https://docs.nvidia.com/nim/bionemo/openfold2/2.6.0/getting-started.md)
  - [Example Requests](https://docs.nvidia.com/nim/bionemo/openfold2/2.6.0/example-requests.md)
- [OpenFold3](https://docs.nvidia.com/nim/bionemo/openfold3/llms.txt)
  - [Overview](https://docs.nvidia.com/nim/bionemo/openfold3/1.6.0/overview.md)
  - [Prerequisites](https://docs.nvidia.com/nim/bionemo/openfold3/1.6.0/prerequisites.md)
  - [Support Matrix](https://docs.nvidia.com/nim/bionemo/openfold3/1.6.0/support-matrix.md)
  - [Getting Started](https://docs.nvidia.com/nim/bionemo/openfold3/1.6.0/getting-started.md)
  - [Example Requests](https://docs.nvidia.com/nim/bionemo/openfold3/1.6.0/example-requests.md)
- [ProteinMPNN](https://docs.nvidia.com/nim/bionemo/proteinmpnn/llms.txt)
  - [Overview](https://docs.nvidia.com/nim/bionemo/proteinmpnn/1.2.0/overview.md)
  - [Prerequisites](https://docs.nvidia.com/nim/bionemo/proteinmpnn/1.2.0/prerequisites.md)
  - [Support Matrix](https://docs.nvidia.com/nim/bionemo/proteinmpnn/1.2.0/support-matrix.md)
  - [Quickstart Guide](https://docs.nvidia.com/nim/bionemo/proteinmpnn/1.2.0/quickstart-guide.md)
  - [Endpoints](https://docs.nvidia.com/nim/bionemo/proteinmpnn/1.2.0/endpoints.md)
- [RFD4-Proteina](https://docs.nvidia.com/nim/bionemo/rfd4-proteina/llms.txt)
  - [Overview](https://docs.nvidia.com/nim/bionemo/rfd4-proteina/1.0.0/overview.md)
  - [Prerequisites](https://docs.nvidia.com/nim/bionemo/rfd4-proteina/1.0.0/prerequisites.md)
  - [Support Matrix](https://docs.nvidia.com/nim/bionemo/rfd4-proteina/1.0.0/support-matrix.md)
  - [Getting Started](https://docs.nvidia.com/nim/bionemo/rfd4-proteina/1.0.0/getting-started.md)
  - [Example Requests](https://docs.nvidia.com/nim/bionemo/rfd4-proteina/1.0.0/example-requests.md)
- [RFdiffusion](https://docs.nvidia.com/nim/bionemo/rfdiffusion/llms.txt)
  - [Overview](https://docs.nvidia.com/nim/bionemo/rfdiffusion/2.3.0/overview.md)
  - [Prerequisites](https://docs.nvidia.com/nim/bionemo/rfdiffusion/2.3.0/prerequisites.md)
  - [Support Matrix](https://docs.nvidia.com/nim/bionemo/rfdiffusion/2.3.0/support-matrix.md)
  - [Quickstart Guide](https://docs.nvidia.com/nim/bionemo/rfdiffusion/2.3.0/quickstart-guide.md)
  - [Endpoints](https://docs.nvidia.com/nim/bionemo/rfdiffusion/2.3.0/endpoints.md)