> This page is for OpenFold2, version 1.2.0.
> For other versions, use one of these documentation indexes:
> - 2.6.0 (Latest) (default): https://docs.nvidia.com/nim/bionemo/openfold2/2.6.0/llms.txt
> - 2.5.0: https://docs.nvidia.com/nim/bionemo/openfold2/2.5.0/llms.txt
> - 2.4.0: https://docs.nvidia.com/nim/bionemo/openfold2/2.4.0/llms.txt
> - 2.3.0: https://docs.nvidia.com/nim/bionemo/openfold2/2.3.0/llms.txt
> - 2.2.0: https://docs.nvidia.com/nim/bionemo/openfold2/2.2.0/llms.txt
> - 2.1.0: https://docs.nvidia.com/nim/bionemo/openfold2/2.1.0/llms.txt
> - 2.0.0: https://docs.nvidia.com/nim/bionemo/openfold2/2.0.0/llms.txt
> - 1.2.0: https://docs.nvidia.com/nim/bionemo/openfold2/1.2.0/llms.txt
> - 1.1.0: https://docs.nvidia.com/nim/bionemo/openfold2/1.1.0/llms.txt
> - 1.0.0: https://docs.nvidia.com/nim/bionemo/openfold2/1.0.0/llms.txt

> For clean Markdown of any page, append .md to the page URL.
> For a complete documentation index, see https://docs.nvidia.com/nim/bionemo/llms.txt.
> For AI client integration (Claude Code, Cursor, etc.), connect to the MCP server at https://docs.nvidia.com/nim/bionemo/_mcp/server.

# Supported Hardware

The OpenFold2 NIM is configured to run on a single GPU, and supports input
sequences with length less than (or-equal-to) 1000 AAs.

## GPU

The OpenFold2 NIM is supported to run on the GPU configurations below.

| GPU | GPU Memory | # of GPUs |
|-----------|----------|----------|
| NVIDIA H100 80GB HBM3 | 80GB | [1] |
| NVIDIA H100 PCIe | 80GB | [1] |
| NVIDIA A100-SXM4-80GB | 80GB | [1] |
| NVIDIA A100 80GB PCIe | 80GB | [1] |


## Storage

NVIDIA recommends at least 380GB of disk space.  The container is roughly 55GB.  Additionally, at startup, the NIM downloads needed data items, if they are
not present on the local filesystem.  These data items are model parameters (roughly 10GB), and a dataset of protein structures (roughly 300GB).

## CPU and System Memory

* At least 64 GB of RAM
* A CPU with at least 8 available cores