> This page is for OpenFold2, version 2.6.0 (Latest) (default).
> For other versions, use one of these documentation indexes:
> - 2.6.0 (Latest) (default): https://docs.nvidia.com/nim/bionemo/openfold2/2.6.0/llms.txt
> - 2.5.0: https://docs.nvidia.com/nim/bionemo/openfold2/2.5.0/llms.txt
> - 2.4.0: https://docs.nvidia.com/nim/bionemo/openfold2/2.4.0/llms.txt
> - 2.3.0: https://docs.nvidia.com/nim/bionemo/openfold2/2.3.0/llms.txt
> - 2.2.0: https://docs.nvidia.com/nim/bionemo/openfold2/2.2.0/llms.txt
> - 2.1.0: https://docs.nvidia.com/nim/bionemo/openfold2/2.1.0/llms.txt
> - 2.0.0: https://docs.nvidia.com/nim/bionemo/openfold2/2.0.0/llms.txt
> - 1.2.0: https://docs.nvidia.com/nim/bionemo/openfold2/1.2.0/llms.txt
> - 1.1.0: https://docs.nvidia.com/nim/bionemo/openfold2/1.1.0/llms.txt
> - 1.0.0: https://docs.nvidia.com/nim/bionemo/openfold2/1.0.0/llms.txt

> For clean Markdown of any page, append .md to the page URL.
> For a complete documentation index, see https://docs.nvidia.com/nim/bionemo/llms.txt.
> For AI client integration (Claude Code, Cursor, etc.), connect to the MCP server at https://docs.nvidia.com/nim/bionemo/_mcp/server.

# Supported Hardware

The OpenFold2 NIM runs on a single GPU, and supports input sequences with
length less than or equal to 2,048 amino acids.

## GPU

The OpenFold2 NIM is supported to run on the GPU configurations below.

| GPU | GPU Memory (GB) | Precision | # of GPUs |
|-----|-----------------|-----------|----------|
| NVIDIA A100 80GB PCIe | 80 | BF16 | [1] |
| NVIDIA A100 40GB PCIe | 40 | BF16 | [1] |
| NVIDIA A100-SXM4-80GB | 80 | BF16 | [1] |
| NVIDIA B200 | 180 | BF16 | [1] |
| NVIDIA B300 | 288 | BF16 | [1] |
| NVIDIA GB10 (DGX Spark) | 128 | BF16 | [1] |
| NVIDIA GB200 | 186 | BF16 | [1] |
| NVIDIA GB300 | 288 | BF16 | [1] |
| NVIDIA GH200 144GB | 144 | BF16 | [1] |
| NVIDIA H100 80GB HBM3 | 80 | BF16 | [1] |
| NVIDIA H100 80GB PCIe | 80 | BF16 | [1] |
| NVIDIA H100 NVL | 94 | BF16 | [1] |
| NVIDIA H200 | 141 | BF16 | [1] |
| NVIDIA H200 NVL | 141 | BF16 | [1] |
| NVIDIA L40S | 48 | BF16 | [1] |
| NVIDIA RTX 6000 Ada Generation | 48 | BF16 | [1] |
| NVIDIA RTX PRO 6000 Blackwell Server Edition | 96 | BF16 | [1] |
| NVIDIA RTX PRO 6000 Blackwell Workstation Edition | 96 | BF16 | [1] |

<Note>
The GB10 features 128 GB of LPDDR5x unified memory shared between the CPU and GPU of the NVIDIA Grace Blackwell Superchip.
</Note>

## Storage

NVIDIA recommends at least 80 GB of disk space. At startup, the NIM downloads model parameters (roughly 5.2 GB) into the NIM cache if they are not present on the local filesystem.

## CPU and System Memory

* At least 64 GB of RAM
* A CPU with at least 8 available cores