Supported Hardware#

Each prediction runs on a single GPU. Starting in 1.6.0, a container given more than one GPU serves requests from all of them concurrently; refer to Configuration Alternatives.

GPU#

The OpenFold3 NIM is supported to run on the GPU configurations below.

GPU

GPU Memory

# of GPUs

NVIDIA H100 80GB HBM3

80GB

1 or more

NVIDIA H100 NVL

94GB

1 or more

NVIDIA H100 PCIe

80GB

1 or more

NVIDIA A100-SXM4-80GB

80GB

1 or more

NVIDIA A100 80GB PCIe

80GB

1 or more

NVIDIA A100-SXM4-40GB

40GB

1 or more

NVIDIA A100 40GB PCIe

40GB

1 or more

NVIDIA H200

141GB

1 or more

NVIDIA H200 NVL

141GB

1 or more

NVIDIA B200

180GB

1 or more

NVIDIA B300

288GB

1 or more

NVIDIA GB200

186GB

1 or more

NVIDIA GB300

288GB

1 or more

NVIDIA GH200 144GB

144GB

1 or more

NVIDIA RTX PRO 6000 Blackwell Server Edition

96GB

1 or more

NVIDIA RTX PRO 6000 Blackwell Workstation Edition

96GB

1 or more

NVIDIA RTX 6000 Ada Generation

48GB

1 or more

NVIDIA L40S

48GB

1 or more

NVIDIA GB10 (DGX Spark)

128GB

1

Note

The GB10 features 128GB of LPDDR5x unified memory shared between CPU and GPU, providing seamless memory access across the Grace Blackwell Superchip architecture. It is listed as 1 rather than 1 or more because a DGX Spark carries a single GB10 superchip, so there is no second GPU for the NIM to start a worker on.

Storage#

NVIDIA recommends at least 80GB of disk space.

The container is roughly 11GB to download and approximately 40GB once unpacked. Model parameters are not included in the container; they are downloaded on first run into the NIM cache directory, which needs a further 15GB. Refer to Getting Started for how to set the cache location.

CPU and System Memory#

  • At least 64 GB of RAM

  • A CPU with at least 8 available cores