Supported Hardware#

The OpenFold3 NIM is configured to run on a single GPU, and supports different sequence length ranges depending on the inference backend:

  • PyTorch backend: Supports sequences from 2 to 4096 amino acids

  • TensorRT-BioNeMo backend: Supports sequences from 4 to 2048 amino acids (optimized for faster inference)

GPU#

The OpenFold3 NIM is supported to run on the GPU configurations below.

GPU

GPU Memory

# of GPUs

NVIDIA H100 80GB HBM3

80GB

[1]

NVIDIA H100 PCIe

80GB

[1]

NVIDIA A100-SXM4-80GB

80GB

[1]

NVIDIA A100 80GB PCIe

80GB

[1]

NVIDIA H200

141GB

[1]

Storage#

NVIDIA recommends at least 80GB of disk space. The container is roughly 61GB, which includes the OpenFold3 model parameters (~6GB) and TensorRT optimized inference engines.

CPU and System Memory#

  • At least 64 GB of RAM

  • A CPU with at least 8 available cores