Support Matrix | NVIDIA BioNeMo NIM Documentation

Supported Hardware

Minimum System Hardware Requirements

CPU Cores	RAM (GB)	NVMe SSD Storage (GB)	GPU Count
4	8	10	1 GPU from the list of Supported NVIDIA GPUs

The NVMe SSD Storage requirement of 10 GB accounts for the ProteinMPNN NIM image size plus additional space for Docker layer caching and temporary files during runtime.

Supported NVIDIA GPUs

The ProteinMPNN NIM requires NVIDIA GPUs with at least 3 GB of GPU Memory. The ProteinMPNN NIM is configured to run on a single GPU and should run on any NVIDIA GPU that meets this minimum memory requirement and has compute capability >7.0. The following configurations have been specifically tested for optimal performance and stability. Use one of the following tested configurations:

GPU	GPU Memory (GB)	Microarchitecture	Precision	GPU Count
A100	40-80	Ampere	FP32/FP16	1
B200	192	Blackwell	FP32/FP16	1
B300	288	Blackwell	FP32/FP16	1
GB10	128	Blackwell	FP32/FP16	1
GB200	192	Blackwell	FP32/FP16	1
GB300	288	Blackwell	FP32/FP16	1
GH200	144	Hopper	FP32/FP16	1
H100	80	Hopper	FP32/FP16	1
H200	141	Hopper	FP32/FP16	1
L40S	48	Ada Lovelace	FP32/FP16	1
RTX 6000 Ada Generation	48	Ada Lovelace	FP32/FP16	1
RTX PRO 6000 Blackwell Workstation Edition	96	Blackwell	FP32/FP16	1

While the minimum GPU memory requirement is 3 GB, the above configurations have been tested for optimal performance and stability. Other NVIDIA GPUs with compute capability >7.0 might work but have not been officially tested.

Set Up the Software Environment

Begin with Docker-supported operating system
Install Docker - minimum version: 23.0.1
Install NVIDIA Drivers - minimum version: 580
Install the NVIDIA Container Toolkit - minimum version: 1.13.5
Verify your container runtime supports NVIDIA GPUs by running

docker run --rm --runtime=nvidia --gpus 1 ubuntu nvidia-smi

Example output:

+-----------------------------------------------------------------------------+
| NVIDIA-SMI 580.126.09             Driver Version: 580.126.09     CUDA Version: 13.0     |
|-------------------------------+----------------------+----------------------+
| GPU  Name        Persistence-M| Bus-Id        Disp.A | Volatile Uncorr. ECC |
| Fan  Temp  Perf  Pwr:Usage/Cap|         Memory-Usage | GPU-Util  Compute M. |
|                               |                      |               MIG M. |
|===============================+======================+======================|
|   0  NVIDIA GeForce ...  Off  | 00000000:01:00.0 Off |                  N/A |
| 41%   30C    P8     1W / 260W |   2244MiB / 11264MiB |      0%      Default |
|                               |                      |                  N/A |
+-------------------------------+----------------------+----------------------+
+-----------------------------------------------------------------------------+
| Processes:                                                                  |
|  GPU   GI   CI        PID   Type   Process name                  GPU Memory |
|        ID   ID                                                   Usage      |
|=============================================================================|
+-----------------------------------------------------------------------------+