Support Matrix | NVIDIA BioNeMo NIM Documentation

Supported Hardware

Minimum System Hardware Requirements

CPU Cores	RAM (GB)	NVMe SSD Storage (GB)	GPU Count
12	64	48	One or More NVIDIA GPU from the list of Supported NVIDIA GPUs

Supported NVIDIA GPUs

The Boltz-2 NIM requires NVIDIA GPUs with at least 48 GB of GPU Memory. While the system can run on any NVIDIA GPU meeting this minimum memory requirement, the following configurations have been specifically tested and optimized using NVIDIA TensorRT (TRT):

GPU	GPU Memory (GB)	Precision	GPU Count
A100	80	BF16	1-2-4-8
H100	80	BF16	1-2-4-8
L40s	48	BF16	1-2-4-8
B200	180	BF16	1-2-4-8
RTX6000 Ada	48	BF16	1-2-4-8

For optimal performance and stability, we recommend using one of the above tested configurations. While other NVIDIA GPUs with 48GB or more memory may work, they have not been officially tested and may exhibit degraded performance or stability issues.

Testing Locally Available Hardware

Begin with Docker-supported operating system
Install Docker - minimum version: 23.0.1
Install NVIDIA Drivers - minimum version: 535
Install the NVIDIA Container Toolkit - minimum version: 1.13.5
Verify your container runtime supports NVIDIA GPUs by running

docker run --rm --runtime=nvidia --gpus all ubuntu nvidia-smi

Example output:

+-----------------------------------------------------------------------------+
| NVIDIA-SMI 535.230.02   Driver Version: 535.230.02    CUDA Version: 12.4    |
|-------------------------------+----------------------+----------------------+
| GPU  Name        Persistence-M| Bus-Id        Disp.A | Volatile Uncorr. ECC |
| Fan  Temp  Perf  Pwr:Usage/Cap|         Memory-Usage | GPU-Util  Compute M. |
|                               |                      |               MIG M. |
|===============================+======================+======================|
|   0  NVIDIA GeForce ...  Off  | 00000000:01:00.0 Off |                  N/A |
| 41%   30C    P8     1W / 260W |   2244MiB / 11264MiB |      0%      Default |
|                               |                      |                  N/A |
+-------------------------------+----------------------+----------------------+
+-----------------------------------------------------------------------------+
| Processes:                                                                  |
|  GPU   GI   CI        PID   Type   Process name                  GPU Memory |
|        ID   ID                                                   Usage      |
|=============================================================================|
+-----------------------------------------------------------------------------+

For more information on enumerating multi-GPU systems, refer to the NVIDIA Container Toolkit’s GPU Enumeration Docs