Supported Hardware#

The OpenFold2 NIM runs on a single GPU, and supports input sequences with length less than (or equal to) 2048 AAs.

GPU#

The OpenFold2 NIM is supported to run on the GPU configurations below.

GPU

GPU Memory (GB)

Precision

# of GPUs

NVIDIA A100 80GB PCIe

80

BF16

[1]

NVIDIA A100 40GB PCIe

40

BF16

[1]

NVIDIA A100-SXM4-80GB

80

BF16

[1]

NVIDIA B200

180

BF16

[1]

NVIDIA B300

288

BF16

[1]

NVIDIA GB10 (DGX Spark)

128

BF16

[1]

NVIDIA GB200

186

BF16

[1]

NVIDIA GB300

288

BF16

[1]

NVIDIA GH200 144GB

144

BF16

[1]

NVIDIA H100 80GB HBM3

80

BF16

[1]

NVIDIA H100 80GB PCIe

80

BF16

[1]

NVIDIA H100 NVL

94

BF16

[1]

NVIDIA H200

141

BF16

[1]

NVIDIA H200 NVL

141

BF16

[1]

NVIDIA L40S

48

BF16

[1]

NVIDIA RTX 6000 Ada Generation

48

BF16

[1]

NVIDIA RTX PRO 6000 Blackwell Server Edition

96

BF16

[1]

NVIDIA RTX PRO 6000 Blackwell Workstation Edition

96

BF16

[1]

Note

The GB10 features 128GB of LPDDR5x unified memory shared between CPU and GPU, providing seamless memory access across the Grace Blackwell Superchip architecture.

Storage#

NVIDIA recommends at least 80GB of disk space. At startup, the NIM downloads model parameters (roughly 5.2GB) into the NIM cache if they are not present on the local filesystem.

CPU and System Memory#

  • At least 64 GB of RAM

  • A CPU with at least 8 available cores