Supported Hardware#

The OpenFold2 NIM is configured to run on a single GPU, and supports input sequences with length less than (or-equal-to) 2048 AAs.

GPU#

The OpenFold2 NIM is supported to run on the GPU configurations below.

GPU

GPU Memory

# of GPUs

NVIDIA H100 80GB HBM3

80GB

[1]

NVIDIA H100 PCIe

80GB

[1]

NVIDIA A100-SXM4-80GB

80GB

[1]

NVIDIA A100 80GB PCIe

80GB

[1]

NVIDIA L40S

48GB

[1]

NVIDIA B200

180GB

[1]

NVIDIA RTX 6000 Ada Generation

48GB

[1]

NVIDIA GB200

186GB

[1]

NVIDIA GB10 (DGX Spark)

128GB

[1]

Note

The GB10 features 128GB of LPDDR5x unified memory shared between CPU and GPU, providing seamless memory access across the Grace Blackwell Superchip architecture.

Storage#

NVIDIA recommends at least 80GB of disk space. The container is roughly 55GB. Additionally, at startup, the NIM downloads model parameters (roughly 10GB) if they are not present on the local filesystem.

CPU and System Memory#

  • At least 64 GB of RAM

  • A CPU with at least 8 available cores