New Tools

With Parabricks 4.6.0 we are releasing a GPU-accelerated pangenome_aware_deepvariant tool. Pangenome-aware DeepVariant is an enhanced version of Google's DeepVariant that leverages pangenome reference graphs (GBZ files) to improve variant calling accuracy, particularly in complex and highly variable genomic regions. It generates pileup images of both reads and pangenome haplotypes near potential variants and uses a Convolutional Neural Network to infer genotypes.