Supported Hardware | NVIDIA BioNeMo NIM Documentation

The OpenFold2 NIM is configured to run on a single GPU, and supports input sequences with length less than (or-equal-to) 2048 AAs.

GPU

The OpenFold2 NIM is supported to run on the GPU configurations below.

GPU	GPU Memory (GB)	Precision	# of GPUs
NVIDIA A100 80GB PCIe	80	BF16	[1]
NVIDIA A100-SXM4-80GB	80	BF16	[1]
NVIDIA B200	180	BF16	[1]
NVIDIA B300	288	BF16	[1]
NVIDIA GB10 (DGX Spark)	128	BF16	[1]
NVIDIA GB200	186	BF16	[1]
NVIDIA GB300	288	BF16	[1]
NVIDIA GH200 144GB	144	BF16	[1]
NVIDIA H100 80GB HBM3	80	BF16	[1]
NVIDIA H100 80GB PCIe	80	BF16	[1]
NVIDIA H200	141	BF16	[1]
NVIDIA L40S	48	BF16	[1]
NVIDIA RTX 6000 Ada Generation	48	BF16	[1]
NVIDIA RTX PRO 6000 Blackwell Workstation Edition	96	BF16	[1]

The GB10 features 128GB of LPDDR5x unified memory shared between CPU and GPU, providing seamless memory access across the Grace Blackwell Superchip architecture.

Storage

NVIDIA recommends at least 80GB of disk space. The container is roughly 55GB. Additionally, at startup, the NIM downloads model parameters (roughly 10GB) if they are not present on the local filesystem.

CPU and System Memory

At least 64 GB of RAM
A CPU with at least 8 available cores