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Supported Hardware

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The OpenFold2 NIM runs on a single GPU, and supports input sequences with length less than or equal to 2,048 amino acids.

GPU

The OpenFold2 NIM is supported to run on the GPU configurations below.

GPUGPU Memory (GB)Precision# of GPUs
NVIDIA A100 80GB PCIe80BF16[1]
NVIDIA A100 40GB PCIe40BF16[1]
NVIDIA A100-SXM4-80GB80BF16[1]
NVIDIA B200180BF16[1]
NVIDIA B300288BF16[1]
NVIDIA GB10 (DGX Spark)128BF16[1]
NVIDIA GB200186BF16[1]
NVIDIA GB300288BF16[1]
NVIDIA GH200 144GB144BF16[1]
NVIDIA H100 80GB HBM380BF16[1]
NVIDIA H100 80GB PCIe80BF16[1]
NVIDIA H100 NVL94BF16[1]
NVIDIA H200141BF16[1]
NVIDIA H200 NVL141BF16[1]
NVIDIA L40S48BF16[1]
NVIDIA RTX 6000 Ada Generation48BF16[1]
NVIDIA RTX PRO 6000 Blackwell Server Edition96BF16[1]
NVIDIA RTX PRO 6000 Blackwell Workstation Edition96BF16[1]

The GB10 features 128 GB of LPDDR5x unified memory shared between the CPU and GPU of the NVIDIA Grace Blackwell Superchip.

Storage

NVIDIA recommends at least 80 GB of disk space. At startup, the NIM downloads model parameters (roughly 5.2 GB) into the NIM cache if they are not present on the local filesystem.

CPU and System Memory

  • At least 64 GB of RAM
  • A CPU with at least 8 available cores