What's New?

Parabricks 4.0.0-1 is a major release with many significant changes. It streamlines how users get and set up the software and simplifies deployment on different platforms. If you are an existing Parabricks user, review this section to understand the major changes.

Licensing Changes

There is no license required to use Clara Parabricks. The container works out of the box once downloaded.

Users who would like Enterprise Support can purchase NVIDIA AI Enterprise licenses, which provides full-stack support for Clara Parabricks and many other NVIDIA software offerings.

To enquire about Enterprise Support for Clara Parabricks, please reach out to the NVIDIA genomics team at https://www.nvidia.com/en-gb/clara/genomics/

Supported Tools

Parabricks 4.0.0-1 has a significantly reduced set of tools. We are focusing primarily on the following tools:

If you would like access to one or more of the tools that are no longer available, contact us in the developer forum.

WDL/Nextflow Workflows

Parabricks containers are compatible with WDL and NextFlow for building customized workflows, intertwining GPU- and CPU-powered tasks with different compute requirements, and deploying at scale.

These enable workflows to be deployed on cloud batch services as well as local clusters (e.g. SLURM) in a well managed process, pulling from a combination of Clara Parabricks and third-party containers and running these on pre-defined nodes.

_images/Workflow diagram.png

For further information on running these workflows, and to see the open-source reference workflows, which can be easily forked/edited, visit the Clara Parabricks Workflows repository. This repository includes recommended instance configurations for deploying the GPU-based tools on cloud and can be easily forked/edited for your own purposes.

Improvements

Bug Fixes

  • Corrected rna_fq2bam sample code. The --read-files-command zcat, while not a required parameter, is needed for correct operation with compressed FASTQ files.

  • Updated the list of supported haplotypecaller options.

  • Corrected GATK sample code.

  • Fixed an fq2bam bug that occurred when many Ns are present in the fastq files.

General deepvariant performance improvements.

For further information see the Clara Parabricks datasheet.